Galantamine improves cognition, behavioral symptoms and functioning: a 6-month non-interventional study
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چکیده
Galantamine improves cognition, behavioral symptoms and functioning: a 6-month non-interventional study Triantafyllos Doskas, Konstantinos Giatas, Dimitrios Oikonomidis, Magdalini Tsolaki, Antonios Politis, Xenofon Fitsioris, Vassiliki Kontogianni, Nikolaos Makris, Ioannis Papatriantafyllou, Stamatia Rigopoulou, Paraskevi Sakka, Vassileios Vagenas, Georgios Varelas, Konstantinos Gatos, Andreas Fortos, Nikolaos Taskos, Angeliki Mestoussi, Michalis Vikelis From 1 International Congress on Neurobiology and Clinical Psychopharmacology and European Psychiatric Association Conference on Treatment Guidance Thessaloniki, Greece. 19-22 November 2009
منابع مشابه
Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease.
Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled studies of up to 6 months duration, galantamine significantly improved cognitive...
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Conclusions The final results of the study showed that galantamine with addition memantine improves cognition, behavioural symptoms, and the general well-being of patients with cognitive impairment: Alzheimer’s disease. The incidence of adverse events was not significant and a very good profile of tolerability and safety was observed. Author details Servicio de Psiquiatría. Hospital Italiano de...
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Alpha7 nicotinic acetylcholine receptor (α7 nAChR) agonists may be valuable treatments for negative symptoms and cognitive impairment in schizophrenia. Unfortunately, chronic exposure to an agonist may reduce the receptor's sensitivity. Therefore, we combined CDP-choline, a dietary source of the direct agonist choline, with galantamine, a positive allosteric modulator (PAM) of nicotinic acetylc...
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BACKGROUND Deficient cholinergic function contributes to the cognitive and behavioral signs and symptoms of Alzheimer disease (AD). A successful treatment approach in AD has been the enhancement of cholinergic function by cholinesterase inhibitors. REVIEW SUMMARY Galantamine is a cholinesterase inhibitor and allosteric modulating ligand at nicotinic cholinergic receptors. Galantamine 24 mg/d ...
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